Effects of low doses of caffeine on cognitive performance, mood and thirst in low and higher caffeine consumers. No evidence of dehydration with moderate daily coffee intake: a counterbalanced cross-over study in a free-living population. National Academies Press (US) 2014.Įvans J, Richards JR, Battisti AS. Caffeine effects on the cardiovascular system. Planning Committee for a Workshop on Potential Health Hazards Associated with Consumption of Caffeine, Food and Nutrition Board, Board on Health Sciences Policy, Institute of Medicine. Short-term effects of high-dose caffeine on cardiac arrhythmias in patients with heart failure: a randomized clinical trial. Zuchinali P, Souza GC, Pimentel M, et al. The safety of ingested caffeine: a comprehensive review. Temple JL, Bernard C, Lipshultz SE, Czachor JD, Westphal JA, Mestre MA. Neurobehavioral hazard identification and characterization for caffeine. National Institute of Health (NIH) National Institute of Mental Health.
Caffeine consumption and self-assessed stress, anxiety, and depression in secondary school children. Caffeine induces neurobehavioral effects through modulating neurotransmitters. Does caffeine trigger or treat headaches?Īlasmari F. Symptoms attributed to consumption of caffeinated beverages in adolescents. Sojar SH, Shrier LA, Ziemnik RE, Sherritt L, Spalding AL, Levy S. Mitchell DC, Knight CA, Hockenberry J, Teplansky R, Hartman TJ. Spilling the beans: how much caffeine is too much?. If you would like to learn more about NutriScience’s natural caffeine ingredients, click the logos below.US Food and Drug Administration (FDA). They found differences in blood glucose and insulin levels and differences in C-peptide responses. Researchers investigated why acute synthetic caffeine ingestion leads to impaired glucose tolerance, while chronic consumption of naturally sourced caffeine may actually decrease the risk of development of Type II diabetes. This means a quicker spike, but it also means a quicker crash – and this is the key problem with synthetic caffeine.Īdditionally, there is evidence that blood glucose response is different between synthetic and natural caffeine. According to these experts, synthetic caffeine will absorb through the digestive system much faster than natural caffeine. There are a number of health experts that believe that natural caffeine behaves differently from synthetic caffeine, based on their experiences. These radioisotope and fluorescent properties of synthetic caffeine could be potentially concerning.Īlthough the basic chemical formula of caffeine is the same, whether it is naturally extracted from tea or synthesized chemically, most people assume that the health effects are the same. Additionally, synthetic caffeine is fluorescent. In fact, this highly sophisticated chemical analysis can be used to chemically distinguish synthetic from natural caffeine. This is due to the different sources of the carbon molecules in caffeine.
Synthetic caffeine can be distinguished from natural caffeine using radioisotope analysis because there are different radioisotopes of carbon in the natural form vs the synthetic form. There are other chemical differences between natural and synthetic caffeine. This is one property that leads to different physiological actions. This means that it is amorphous and does not contain any water molecules. On the other hand, synthetic caffeine is anhydrous. This means that one molecule of caffeine contains between 4 and 5 molecules of water in crystalline form. Natural caffeine is a crystalline 4/5 hydrate.
However, there are chemical differences between them. Consumers want naturally sourced ingredients, and caffeine is no exception.īoth natural and synthetic caffeine have the same molecular formula – C 8H 10N 4O 2. Chemical differences between synthetic and natural caffeine can lead to different physiological effects.
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